They have different amounts of DIM per capsule (200 or 250mg), and the DIM 250 Complex also contains an array of different supportive ingredients designed to maximize usefulness for use during menopause, including various vegetable powders, Broccoli seed extract, Vitamin D-3, and herbal Dong Quai. testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. DIM – Diindolylmethane is an androgen antagonist! When taken correctly in the small amounts found in foods, diindolymethane is likely safe. Hello Marva, DIM 200, and DIM 250 Complex are different supplements. Diindolylmethane is formed in the body from plant substances contained in “cruciferous” vegetables such as cabbage, Brussels sprouts, cauliflower, and broccoli. DIM is safe for most individuals, but you may experience some mild detox-like symptoms including: Fatigue; Headache; Nausea; Dark-colored urine; Changes in menstrual cycle While there are promising benefits that can come with taking DIM, there are some potential side effects to take note. Diindolylmethane may cause a decrease in the amount of sodium in the body . After all, any supplement, even if it’s all natural, may have negative side effects. DIM Supplement Side Effects and Dosage. DIM has also been shown to favorably alter the ratios of “good” to “bad” estrogen. Notably, falling down is the most prevalent cause of accidental death among people 65 and older. Learn more about Diindolylmethane uses, benefits, side effects, interactions, safety concerns, and effectiveness. Diindolylmethane Side Effects Rash, nausea, vomiting, headache, arthralgia and hot flashes have been reported. Side Effects. Diindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage and cauliflower.It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer .. DIM demonstrated anti-inflammatory , antiproliferative and chemopreventive effects … Side effects of DIM supplements are common and may include headaches, dehydration, as well as joint pain, aching, or cracking. Diindolylmethane (DIM) reduces the level of "bad estrogen" (16-hydroxyestrone estrogen metabolites) while increasing "good" estrogen (2-hydroxyestrone estrogen metabolites). But are the possible benefits worth the risk? The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions. Studies suggest it protects the body from xenoestrogens, compounds that mimic and intensify the effects of estrogen. Diindolylmethane Side Effects. DIM supplements is commonly taken in doses of 100 mg to 200 mg. Nature's Way DIM Plus is used for estrogen metabolism which is the breakdown of estrogen in the liver attempting to eradicate it. DIM blocks the effects of testosterone. It further confirmed results and safety reported from previous studies in adult humans and the adult animal model. DIM possesses hormone-modulating effects. DIM side effects. In light of this, are there any DIM adverse consequences? WebMd.com claims DIM is most likely safe. DIM side effects caused by hyponatremia are far more likely to be experienced by the elderly. Higher doses (greater than 100mg) of isolated pure DIM can saturate tissues and block androgen (e.g. Keep in mind that the safety profile of DIM is relatively unknown, given the lack of well-designed clinical studies. 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